Dr. Lea Da Silva Veras!
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Written by Serzhan Sakipov   

Dr. Lea Da Silva Veras! Cool


 After Doctor's Hooding Ceremony:


Maria Kurnikova and Lea Veras 




 Not full group picture. From left to right: Serzhan Sakipov,  Maria Kurnikova, Lea Veras



Theoretical/computational chemistry and biophysics
Group Information - First Page Section
Written by Nikolay Simakov   
  We are especially interested in developing functional models of membrane proteins, such as ion channels, toxins, signaling and regulatory proteins.

Functioning of membrane proteins is vital to human health. Malfuncion of ion channels, for example, results in such disparate deseases as cystic fibrosis, influenza, migraines and epilepsy. In brain and heart ion channels orchestrate all electrical signals, which are essencial for learning, memory, perseption and muscle control. In kidney, regulatory proteins are responsible for water balance and bone restoration. Almost 30% of modern drugs target membrane proteins. However, progress in target-specific drug-development for membrane proteins has been hindered by their relatively poorly understood mechanisms and structure.

Theoretical modeling is one crucially important component for understanding structure-function relationships in proteins. We are developing hierarchical models of protein that can span multiple time and length-scales needed to predict experimentally measurable properties, yet use fundamental laws of nature at the atomistic resolution.  We use methods of computational chemistry: quantum mechanics, molecular dynamics and continuum electrostatics, as well as docking algorithms, drift-diffusion equations and homology modeling.

Some of the projects we are working on are described in Research   


© 2015 Maria Kurnikova's Research Group
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